Careers
CV6-168 is a first-in-class, specific, oral small molecule inhibitor of dUTPase, developed to work in combination with standard chemotherapies that block DNA synthesis in cancer cells — known as thymidylate synthase (TS) inhibitors, such as 5-FU and pemetrexed.
TS inhibitors work by depleting thymine (T), one of the four essential DNA building blocks (A, T, C, and G). Without thymine, cancer cells cannot replicate their DNA properly, halting their growth. However, many cancers develop resistance — either by bypassing the blockade or evolving over time — limiting the effectiveness of these cornerstone therapies.
Benefits
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Current Opportunities
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